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"We, including scientists, have considered ourselves as sort of the pinnacle of evolution," noted lead researcher Bruce Lahn, a University of Chicago geneticist whose studies appear in Friday's edition of the journal Science.
"There's a sense we as humans have kind of peaked," agreed Greg Wray, director of Duke University's Center for Evolutionary Genomics.
In fact, the variations were so common they couldn't be accidental mutations but instead were probably due to natural selection, where genetic changes that are favorable to a species quickly gain a foothold and begin to spread, the researchers report.
Lahn offers an analogy: Medieval monks would copy manuscripts and each copy would inevitably contain errors — accidental mutations.
For ASPM, the variation arose about 5,800 years ago, roughly correlating with the development of written language, spread of agriculture and development of cities, he said.
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